COGNITION

4x Neuronal ATP Synthesis with 5x less dose

The brain is a highly energetic organ, using 20% of the body’s resting energy while representing only 2% of body mass. Neurons require a constant supply of ATP for essential processes like synaptic activity, ion gradient maintenance, and neurotransmitter release.

Energy production in neurons

In neuronal cells, CLONAPURE® exhibited an effect roughly four times higher than CrM, indicating superior bioenergetic performance. Notably, its efficacy was observed even at concentrations up to five times lower, reinforcing its enhanced cellular potency and efficiency (Hernández-Bueno et al., 2025).

Superior efficacy at any dose:
+11% ATP vs. +2.7% with creatine monohydrate
Faster and more sustained energy phosphagen system activation.
Clear potential under energy stress situations:
Effective in sleep loss, depression, and neurodegeneration

References:
1. Hernández-Bueno A, et al (2025) Clonapure® vs Creatine Monohydrate on ATP Synthesis in a Human Neuron Cell line. J Neurol Exp Neural Sci 7: 158